Should Treatment of Sepsis Include Statins?
نویسندگان
چکیده
منابع مشابه
Should treatment of sepsis include statins?
During the past decade, HMG-CoA reductase inhibitors (statins) have been shown to improve survival in patients with cardiovascular disease. Initially, the beneficial effects of statins were attributed simply to lipid reduction1; however, more recent data suggest that “pleiotropic” properties such as improvement of endothelial dysfunction, increased nitric oxide bioavailability, and antioxidativ...
متن کاملREVIEWARTICLES Statins and sepsis
Severe sepsis and septic shock is common and frequently fatal. Over the last few years, the primary treatments demonstrated to improve outcome from several major clinical trials have finally emerged. However, translating these recent therapeutic advances to routine clinical practice has proven controversial, and new approaches of additional strategies are continued to be developed. Given their ...
متن کاملStatins and sepsis
1 Angle PJ, Halpern SH, Leighton BL, Szalai JP, Gnanendran K, Kronberg JE. A randomized controlled trial examining the effect of naproxen on analgesia during the second day after cesarean delivery. Anesth Analg 2002; 95: 741–5 2 American Academy of Pediatrics Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics 1994; 93: 137–50 3 Fenton C, Keating GM, Wagsta...
متن کاملStatins and Sepsis
tional Ang-2 allele are protected from lung injury and vascular leak (7). Serum from both patients with sepsis (7) and those with ALI (6) disrupts endothelial barrier function, via a mechanism that is blocked via Ang-2 blockade (6, 7). These deleterious effects of Ang-2 on the endothelial barrier function appear to be mediated via a conditional antagonism of the tyrosine kinase receptor Tie 2, ...
متن کاملStatins and Sepsis Literature Review
Recent data suggest that, in addition to improving dyslipidemia, statin may reduce the risk of infections and infectionrelated complications. The aim of this study is to make a review of the literature about the effects of statins on clinically relevant outcomes of patients admitted to the hospital and having an infection and/or sepsis, principally in terms of intensive care unit admissions and...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000160382.01347.ff